The University of the Philippines Manila College of Medicine (CM) is the medical school of the University of the Philippines Manila, the oldest constituent university of the University of the Philippines System. Its establishment in 1905 antedates the foundation of the UP System and makes it one of the oldest medical schools in the country. The Philippine General Hospital, the national university hospital, serves as its teaching hospital.

During World War II it is said that the College of Medicine was the only unit of the University of the Philippines System that continued its operations. Thus the Dean of the college then concurrently served as the President of the system.

The College is the first medical college in the country to offer a shortened medical curriculum from a two-degree, nine-year standard medical program into the seven-year medical curriculum or the Integrated Arts Medicine Program (INTARMED). This program admits high school graduates directly into the College and includes one year of internship.

UPCM has been designated as a Center of Excellence in Medical Education by the Commission on Higher Education (CHED).